Izimbangela ze-psoriasis zibandakanya izakhi zofuzo, amasosha omzimba, ezemvelo nezinye izici, futhi i-pathogenesis yayo ayikacaci ngokuphelele.
1. Izici zofuzo
Ucwaningo oluningi luye lwabonisa ukuthi izici zofuzo zidlala indima ebalulekile ku-pathogenesis ye-psoriasis. Umlando womndeni walesi sifo ubalelwa ku-10% kuya ku-23.8% weziguli eChina futhi cishe u-30% emazweni angaphandle.Amathuba okuba nengane ene-psoriasis angama-2% uma kungekho mzali onalesi sifo, angama-41% uma bobabili abazali benalesi sifo, kanye no-14% uma umzali oyedwa enalesi sifo.Ucwaningo lwamawele ahlobene ne-psoriasis lubonise ukuthi amawele e-monozygotic anamathuba angama-72% okuba nesifo ngesikhathi esifanayo futhi amawele e-dizygotic anamathuba angu-30% okuba nesifo ngesikhathi esifanayo. Ngaphezu kwe-10 okuthiwa i-susceptibility loci ikhonjwe ehlotshaniswa kakhulu nokuthuthukiswa kwe-psoriasis.
2. Izici zamasosha omzimba
Ukusebenza okungavamile kwe-T-lymphocyte kanye nokungena ku-epidermis noma i-dermis yizici ezibalulekile ze-pathophysiological ze-psoriasis, eziphakamisa ukubandakanyeka kwamasosha omzimba ekuthuthukiseni nasekuqhubekeleni phambili kwesifo.Ucwaningo lwakamuva lubonise ukuthi ukukhiqizwa kwe-IL-23 ngamaseli e-dendritic namanye amangqamuzana e-antigen-presenting (APCs) kudala ukuhlukaniswa nokwanda kwama-CD4 + umsizi we-T lymphocyte, amaseli e-Th17, namaseli avuthiwe e-Th17 ahlukene angafihla izici ezihlukahlukene zamaselula ezifana ne-Th17 ezifana njenge-IL-17, IL-21, kanye ne-IL-22, evuselela ukwanda ngokweqile kwamangqamuzana akha i-keratin noma impendulo yokuvuvukala kwamaseli e-synovial. Ngakho-ke, amaseli we-Th17 kanye ne-IL-23 / IL-17 axis angase adlale indima ebalulekile ku-pathogenesis ye-psoriasis.
3. Izemvelo kanye Nezimo Ze-Metabolic
Izici zemvelo zidlala indima ebalulekile ekuqaliseni noma ekwandiseni i-psoriasis, noma ekwandiseni isifo, okuhlanganisa izifo, ukucindezeleka kwengqondo, imikhuba emibi (isb., ukubhema, ukudakwa), ukuhlukumezeka, kanye nokusabela emithini ethile.Ukuqala kwe-pitting psoriasis kuvame ukuhlotshaniswa ne-acute streptococcal infection ye-pharynx, futhi ukwelashwa okulwa nokutheleleka kungaholela ekuthuthukisweni nasekunciphiseni noma ukukhululwa kwezilonda zesikhumba. Ukucindezeleka kwengqondo (njengokucindezeleka, ukuphazamiseka kokulala, ukusebenza ngokweqile) kungabangela i-psoriasis, ibe yimbi noma iphinde iphinde, futhi ukusetshenziswa kokwelashwa okusikisela kwengqondo kungadambisa isimo. Kuphinde kutholakale ukuthi umfutho wegazi ophakeme, isifo sikashukela, i-hyperlipidemia, isifo se-coronary artery kanye nesifo se-metabolic sivame kakhulu phakathi kweziguli ze-psoriasis.
Isikhathi sokuthumela: Mar-17-2023
