Izimbangela ze-psoriasis zifaka phakathi izakhi zofuzo, amasosha omzimba, ezemvelo nezinye izici, futhi imbangela yayo ayikacaci ngokuphelele.
1. Izici zofuzo
Izifundo eziningi zikhombisile ukuthi izici zofuzo zidlala indima ebalulekile ekubangeleni i-psoriasis. Umlando womndeni walesi sifo uhlanganisa u-10% kuya ku-23.8% weziguli eShayina kanye no-30% emazweni angaphandle.Amathuba okuba nengane ene-psoriasis angama-2% uma kungekho mzali onesifo, angama-41% uma bobabili abazali benaso lesi sifo, kanye nama-14% uma omunye umzali enaso.Izifundo zamawele ahlobene ne-psoriasis zibonise ukuthi amawele e-monozygotic anethuba elingu-72% lokuba nalesi sifo ngesikhathi esifanayo kanti amawele e-dizygotic anethuba elingu-30% lokuba nalesi sifo ngesikhathi esifanayo. Kutholakale izindawo ezingaphezu kweziyi-10 ezibizwa ngokuthi i-susceptibility loci ezihlotshaniswa kakhulu nokuthuthukiswa kwe-psoriasis.
2. Izici zokuzivikela komzimba
Ukusebenza okungajwayelekile kwama-T-lymphocyte kanye nokungena kwe-epidermis noma i-dermis kuyizimpawu ezibalulekile ze-psoriasis, okubonisa ukubandakanyeka kwesistimu yomzimba ekuthuthukisweni nasekuqhubekeni kwesifo.Izifundo zakamuva zibonise ukuthi ukukhiqizwa kwe-IL-23 ngamaseli e-dendritic kanye namanye amaseli aveza i-antigen (ama-APC) kubangela ukwahlukana nokwanda kwama-lymphocyte e-CD4+ helper T, amaseli e-Th17, kanye namaseli e-Th17 avuthiwe ahlukene angakhipha izinto ezahlukahlukene ezifana ne-Th17 njenge-IL-17, IL-21, kanye ne-IL-22, ezikhuthaza ukwanda ngokweqile kwamaseli akha i-keratin noma impendulo yokuvuvukala kwamaseli e-synovial. Ngakho-ke, amaseli e-Th17 kanye ne-axis ye-IL-23/IL-17 kungadlala indima ebalulekile ekubangeleni i-psoriasis.
3. Izici Zemvelo Nezokwakheka Kwemizimba
Izici zemvelo zidlala indima ebalulekile ekubangeleni noma ekwandiseni i-psoriasis, noma ekwandiseni lesi sifo, okuhlanganisa ukutheleleka, ukucindezeleka kwengqondo, imikhuba emibi (isib. ukubhema, ukuphuza utshwala ngokweqile), ukulimala, kanye nokusabela emithini ethile.Ukuqala kwe-pitting psoriasis kuvame ukuhlotshaniswa nokutheleleka okukhulu kwe-streptococcal kwe-pharynx, futhi ukwelashwa kokulwa nokutheleleka kungaholela ekuthuthukisweni nasekuncishisweni noma ekukhululweni kwezilonda zesikhumba. Ukucindezeleka kwengqondo (njengokucindezeleka, ukuphazamiseka kokulala, ukusebenza ngokweqile) kungabangela ukuba i-psoriasis ivele, ibe yimbi noma ibuye, futhi ukusetshenziswa kokwelashwa okusikisela ngokwengqondo kunganciphisa lesi simo. Kutholakale nokuthi umfutho wegazi ophakeme, isifo sikashukela, i-hyperlipidemia, isifo semithambo yenhliziyo kanye ikakhulukazi i-metabolic syndrome kunezinga eliphezulu lokusabalala phakathi kweziguli ze-psoriasis.
Isikhathi sokuthunyelwe: Mashi-17-2023
